Research Network for Neonatal Diseases Induced by Tissular Fetomaternal Alloimmunization including Neonatal Hemochromatosis

Problems of compatibility between a mother and her child are frequent. The most well-known case can be illustrated by the fetomaternal blood group incompatibility (rhesus factor) which can induce severe anemia of the fetus.

The investigators recently proved that incompatibility between mother and child can concern an organ leading to a tissular alloimmunization. For example, neonatal membranous glomerulonephritis (a kidney disease) can result from this mechanism.

The purpose of this network is to detect and study neonatal diseases induced by tissular fetomaternal alloimmunization. The detection of these diseases will be performed by the mother's serum analysis.

Condition
Glomerulonephritis, Membranous Neonatal Diseases and Abnormalities Hemochromatosis

Further study details as provided by Limoges University Hospital:

Expected Total Enrollment:  100

Genders Eligible for Study:  Female

Criteria

Inclusion Criteria:

Mothers having a child suffering from:

• Neonatal membranous glomerulonephritis
• Unexplained neonatal tubular defect
• Unexplained thrombotic microangiopathy
• Neonatal hemochromatosis

Exclusion Criteria:

• Any cause explaining the child's disease

Please refer to this study by ClinicalTrials.gov identifier  NCT00199628

Vincent Guigonis, MD      +33(0)555 056 358    vincent.guigonis@chu-limoges.fr

France
      Limoges University Hospital, Limoges,  87042,  France; Recruiting

Study chairs or principal investigators

Vincent Guigonis, MD,  Principal Investigator,  Department of Pediatrics, Limoges University Hospital   

Study ID Numbers:  I05001
Last Updated:  March 10, 2006
Record first received:  September 14, 2005
ClinicalTrials.gov Identifier:  NCT00199628
Health Authority: France: Ministry of Health
ClinicalTrials.gov processed this record on 2006-10-10